Atomic structures at last: the ribosome in 2000.

نویسندگان

  • V Ramakrishnan
  • P B Moore
چکیده

Last year, atomic structures of the 50S ribosomal subunit from Haloarcula marismortui and of the 30S ribosomal subunit from Thermus thermophilus were published. A year before that, a 7.8 A resolution electron density map of the 70S ribosome from T. thermophilus appeared. This information is revolutionizing our understanding of protein synthesis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

After the ribosome structures: how does peptidyl transferase work?

Atomic resolution crystal structures of the large subunit published since the middle of August 2000 prove that the peptidyl transferase center of the ribosome, which is the site of peptide-bond formation, is composed entirely of RNA; the ribosome is a ribozyme. They also demonstrate that alignment of the CCA ends of ribosome-bound peptidyl tRNA and aminoacyl tRNA in the peptidyl transferase cen...

متن کامل

The three-dimensional structure of the ribosome and its components.

Exciting progress has been made in the last decade by those who use physical methods to study the structure of the ribosome and its components. The structures of 10 ribosomal proteins and three isolated ribosomal protein domains are known, and the conformations of a significant number of rRNA sequences have been determined. Electron microscopists have made major advances in the analysis of imag...

متن کامل

The ribosome: some hard facts about its structure and hot air about its evolution.

By translating genetically encoded information to synthesize proteins, the ribosome has a central and fundamental role in the molecular biology of the cell. Virtually every molecule made in every cell was made either directly by the ribosome or by enzymes made by the ribosome. Although the ribosome was discovered half a century ago, progress in the field of translation has been revolutionized b...

متن کامل

Supplementary materials for Bayesian inference of initial models in cryo-electron microscopy using pseudo-atoms

Figure 1: FSC curves comparing the references with the reconstructions. The references are the same as shown in the main text, i.e. for the 50S ribosome, RNA Polymerase II and GroEL they are created from the atomic structures at 25 Å, 20 Å and 20 Å respectively, for the 70S ribosome the reference was obtained by the PRIME algorithm and for the last structure (APC/C) the reference is from anothe...

متن کامل

The Ribosome at Atomic Resolution

The 2009 Nobel Prize in Chemistry has been awarded to Venki Ramakrishnan, Tom Steitz, and Ada Yonath for crystallographic studies of the ribosome. The atomic resolution structures of the ribosomal subunits provide an extraordinary context for understanding one of the most fundamental aspects of cellular function: protein synthesis.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Current opinion in structural biology

دوره 11 2  شماره 

صفحات  -

تاریخ انتشار 2001